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Mark Donath, PhD

University of Basel, Switzerland

Jose Halpern, MD

Harvard University

Jakob Appel Oestergaard, PhD 

Aarhus University, Denmark

Ben King, PhD 

Lund University, Sweden

James Lo, MD, PhD

Weill Cornell Medicine

Co-Chairs: Anna Blom and Ben King

Type 2 diabetes is characterised by a loss of glucose homeostasis, caused by insufficient insulin secretion from pancreatic beta-cells, and development of insulin resistance in target cells of muscle, liver and adipose tissue. Recent advances have demonstrated how obesity-related low-level chronic inflammation contributes to insulin resistance, and complement has been implicated in this process. On the other hand, homeostatic auto-/para-crine or even intracellular complement has been implicated in metabolic signaling and proper function of beta-cells and insulin secretion. In addition, diabetes leads to peripheral complications including nephropathy, retinopathy, and neuropathy, affecting tissues which are all also sensitive to complement attack, as demonstrated by human deficiencies and GWAS studies.


 9:00 - 9:05 Introduction

 9:05 - 9:45 

Introductory Talk

Professor Marc Donath, University of Basel, Switzerland

Immunometabolism and diabetes: physiology, pathology and treatment


 9:50 - 10:30 

Complement in peripheral complications of diabetes

Professor Jose Halperin: Harvard, USA

A Role of Complement and CD59 in the Pathogenesis of Diabetes Complications and of Glycated CD59 as a Diabetes Biomarker

 10:35 - 11:05 Dr Jakob Appel Oestergaard: Aarhus University, Denmark

The lectin pathway in diabetic kidney disease

 11:05 - 11:25 Break
 11:25 - 11:55 Complement in beta-cell function
  Dr Ben King: Lund University, Sweden

Non-canonical roles of intracellular CD59-IRIS splice isoforms in insulin secretion

 12:00 - 12:30 Assistant Professor James Lo: Cornell University, USA

Alternative complement pathway regulation of beta cells in diabetes


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ICS promotes advances of complement research and development through the encouragement of cooperative educational programs, clinical applications, and professional standards in the complement field.
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